Premium
Familial polyposis
Author(s) -
Decosse Jerome J.,
Adams Mark B.,
Condon Robert E.
Publication year - 1977
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197701)39:1<267::aid-cncr2820390141>3.0.co;2-x
Subject(s) - familial adenomatous polyposis , medicine , colorectal cancer , gardner syndrome , colectomy , genetic predisposition , cancer , adenomatous polyposis coli , prophylactic surgery , disease , gastroenterology , breast cancer
Familial polyposis is a genetically‐transmitted disease characterized by multiple adenomatous colorectal polyps and a high risk for development of adeno‐carcinoma. Familial polyposis and Gardner's syndrome should be differentiated from other genetically‐linked polyposis syndromes lacking a predisposition for cancer. Total colectomy and ileorectal anastomosis, aggressive follow‐up and intensive surveillance of non‐polyp bearing relatives can reduce the risk of developing cancer. From an epidemiologic point of view, polyposis is a valuable model for the study of the interaction of genetic and environmental factors in the genesis of colon cancer.