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Malignant (fibrous) histiocytoma arising in association with a bone infarct in sickle‐cell disease: Coincidence or cause‐and‐effect?
Author(s) -
Mirra Joseph M.,
Gold Richard H.,
Marafiote Richard
Publication year - 1977
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197701)39:1<186::aid-cncr2820390130>3.0.co;2-4
Subject(s) - medicine , medullary cavity , disease , pathology , sarcoma , bone sarcoma , infarction , cell , myocardial infarction , biology , genetics
A patient with homozygous‐S sickle‐cell disease complicated by malignant (fibrous) histiocytoma arising within a tibial medullary infarct is reported. This is the ninth reported case of human sarcoma associated with bone infarct and the first associated with sickle‐cell disease. Evidence for a causal relationship is presented.