Premium
Intranuclear rodlets in an intrathyroid tumor associated with hyperparathyroidism
Author(s) -
Sherwin Russell P.,
Kaufman Carole,
Dermer Gerald R.,
Monroe Stuart A.
Publication year - 1977
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197701)39:1<178::aid-cncr2820390129>3.0.co;2-a
Subject(s) - histopathology , pathology , thyroid , medicine , biology , endocrinology
A tumor excised from the thyroid gland has been shown by electron microscopy to contain distinctive, intranuclear rodlets. This is the first report of such rodlets in a non‐neuronal human tumor. While the parathyroid‐like hormonal activity, histopathology, and clinical course are consistent with a parathyroid adenoma, the finding of the rodlets raises the question of origin from a special, neuron‐related cell of the parathyroid or thyroid. The unusual cellular granularity and the abundant interstitial fibrillae also suggest an unusual cell of origin. Alternatively, a special metabolic activity may account for the rodlets, or they may have been overlooked in prior studies of adenomas.