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Vagal body tumor (nonchromaffin paraganglioma, chemodectoma, and carotid body‐like tumor) with cervical node metastasis and familial association. Ultrastructural study and review
Author(s) -
Kahn Leonard B.
Publication year - 1976
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197612)38:6<2367::aid-cncr2820380625>3.0.co;2-3
Subject(s) - paraganglioma , medicine , carotid body , chemodectoma , pathology , metastasis , ultrastructure , biopsy , anatomy , cancer , carotid arteries
A case of a vagal body tumor with a solitary cervical node metastasis is described. There was a remarkable familial association: a biopsy‐proven paraganglioma occurred in two members of the patientapos;s family and there was a strong clinical suspicion of a paraganglioma in two others. In a review of the literature, eight patients with metastasizing vagal body tumors and eight patients in whom the vagal body tumor was a component of multicentric presentation of paragangliomas were found. Only one other patient in whom there was a familial occurrence involving a vagal body tumor has been reported. Ultrastructural study of the cervical node metastasis revealed the presence of light and dark chief cells containing scanty, membrane‐bound, densecore, neurosecretory‐type granules. Atypical granules were noted in a few of the dark cells. Nerve fibers, synaptic vesicles, and sustentacular cells, such as occur in normal paraganglionic tissue, were not observed in this tumor.