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Preoperative cell‐mediated immune status of gastric cancer patients
Author(s) -
Orita Kunzo,
Miwa Hiroaki,
Fukuda Hanzo,
Yumura Masahito,
Uchida Yoshio,
Mamnami Tetsuya,
Konaga Eiji,
Tanaka Sanae
Publication year - 1976
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197612)38:6<2343::aid-cncr2820380621>3.0.co;2-t
Subject(s) - medicine , immune system , cell mediated immunity , cancer , immunity , immunology , antigen , cellular immunity , cell , tuberculin , in vitro , rosette (schizont appearance) , peripheral blood , macrophage , pathology , biology , tuberculosis , biochemistry , genetics
The status of cell‐mediated immunity was studied in 360 patients with gastric cancer before surgery. For the skin test, tuberculin and DNCB were employed. For the in vitro test, the blastogenesis of peripheral blood lymphocytes to phytohemagglutinin (PHA), the ratio of rosette‐forming T cells to sheep blood red cells, and the macrophage migration inhibitory factor against autochthonous tumor antigens were measured. As a result, it was found that in progressive gastric cancers the cell‐mediated immunity decreased specifically or nonspecifically, especially the DNCB reaction; and the blastogenesis against PHA showed an inverse correlation to the advance of gastric cancer.