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The effect of cytosine arabinoside on platelet aggregation
Author(s) -
Gagliano Robert G.,
Terrebonne Anne M.,
Alperin Jack B.,
Costanzi John J.
Publication year - 1976
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197612)38:6<2247::aid-cncr2820380609>3.0.co;2-z
Subject(s) - cytosine , platelet , in vivo , in vitro , medicine , pharmacology , platelet aggregation , thrombin , epinephrine , biochemistry , chemistry , biology , dna , genetics
Abstract Platelet aggregation induced by ADP, collagen, epinephrine, and thrombin was studied in patients with acute leukemia in complete remission, before and after a continuous 5‐day intravenous infusion of cytosine arabinoside at a dose of 100 mg/m 2 per day. Aggregation was also measured in normal subjects with cytosine arabinoside added in vitro. Cytosine arabinoside had no significant effect on platelet aggregation after either in vitro or in vivo administration.