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Familial Hodgkin's disease and associated cancer. A Clinical‐Pathologic Study
Author(s) -
Lynch Henry T.,
Saldivar Victor A.,
Guirgis Hoda A.,
Terasaki Paul I.,
Bardawil Wadi A.,
Harris Randall E.,
Lynch Jane F.,
Thomas Robert
Publication year - 1976
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197611)38:5<2033::aid-cncr2820380528>3.0.co;2-p
Subject(s) - medicine , etiology , disease , cancer , family aggregation , pathology , oncology
The etiology of Hodgkin's disease is complex, as is evident in studies suggesting the importance of horizontal transmission, occupational factors, racial and ethnic background, and familial, genetic factors, or both, including HL‐A associations. The present study is of a remarkable kindred in which Hodgkin's disease was histologically verified in two sibships involving second‐cousins related through maternal great‐grandparents. Cancer of the lung, breast, endometrium, ovary, pancreas, and brain, as well as leukemia and Wilms' tumor, occurred in first and second‐degree relatives of the Hodgkin's patients. HL‐A haplotypes in patients with Hodgkin's disease in this family showed HL‐AB5 or HL‐ABW35, an association confirmed in other reports. The findings of associated malignant neoplasms in familial Hodgkin's disease, here and elsewhere in the literature, suggest that in the quest for etiology of Hodgkin's disease one must view the disorder eclectically, with a painstaking search for multiple etiologies, genetic and environmental.