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Nonspecific lymphocyte cytotoxicity in patients with malignant melanoma, renal cell carcinoma, and sarcomas, and in nontumor patients
Author(s) -
Bukowski Ronald M.,
Barna Barbara,
Deodhar Sharad D.,
Hewlett James S.
Publication year - 1976
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197611)38:5<1962::aid-cncr2820380517>3.0.co;2-3
Subject(s) - melanoma , medicine , cytotoxicity , renal cell carcinoma , sarcoma , cytotoxic t cell , cancer research , cell , pathology , peripheral blood mononuclear cell , lymphocyte , fibroblast , carcinoma , cell culture , immunology , oncology , in vitro , biology , biochemistry , genetics
Mononuclear cell‐mediated tumor cell destruction was studied in 114 patients with malignant melanoma, renal cell carcinoma, or sarcomas, and in 122 nontumor‐bearing control subjects, with the use of the microcytotoxicity assay. Cytotoxic reactions were found in all patients and control groups against melanoma, renal carcinoma, sarcoma, and fibroblast‐derived cell cultures; mean levels of cytotoxicity against allogeneic combinations of tumor cells and fibroblasts were similar in tumor‐bearing and control patients. These results support the concept that the reactions found represent nonspecific cytotoxicity.