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Intracavitary bleomycin in the management of malignant effusions
Author(s) -
Paladine William,
Cunningham Thomas J.,
Sponzo Robert,
Donavan Mark,
Olson Kenneth,
Horton John
Publication year - 1976
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197611)38:5<1903::aid-cncr2820380506>3.0.co;2-a
Subject(s) - medicine , bleomycin , toxicity , thoracostomy , surgery , ovarian carcinoma , bone marrow , chemotherapy , pathology , cancer , ovarian cancer , pneumothorax
Instilled bleomycin and thoracostomy were utilized in 38 patients with malignant pleural effusions; the therapy produced a complete or partial response rate of 63%. Toxicity was minimal. In patients with intraperitoneal effusions, bleomycin instillation after drainage produced a complete or partial response in 36%. One patient had severe hypotension and fever. Patients with ovarian and breast carcinoma responded best, among them, effusions were controlled in greater than 70%. Because of its low systemic toxicity, absence of marrow toxicity, and virtual absence of discomfort, we think that the local instillation of bleomycin is indicated in the management of malignant effusions.