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Therapeutic trial of aniline mustard in patients with advanced cancer. Comparison of therapeutic response with cytochemical assessment of tumor cell β‐glucuronidase activity
Author(s) -
Young Charles W.,
Yagoda Alan,
Bittar Edward S.,
Smith Steven W.,
Grabstald Harry,
Whitmore Willet
Publication year - 1976
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197611)38:5<1887::aid-cncr2820380504>3.0.co;2-#
Subject(s) - medicine , cancer , prostate cancer , concomitant , clinical trial , therapeutic effect , prostate , oncology , pathology , urology
Seventy‐eight patients with advanced cancer received an adequate therapeutic trial with aniline mustard (NSC 18429). Significant anticancer activity with clinical benefit was demonstrated in five patients with cancer of the prostate and one patient with renal cancer. β‐glucuronidase levels in aspirate and imprint preparations of tumor cells were assessed by a timed cytochemical technique. A partial correlation appeared to exist between very intense glucuronidase staining and tumor regression in prostate and kidney lesions; however, these high levels were observed only rarely. Sequential observations in two patients demonstrated loss of enzymatic activity concomitant with development of clinical relapse.