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Chromosome studies in “preleukemia”. III. myelofibrosis
Author(s) -
Nowell Peter,
Jensen Julie,
Gardner Frank,
Murphy Scott,
Chaganti R. S. K.,
German James
Publication year - 1976
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197611)38:5<1873::aid-cncr2820380502>3.0.co;2-i
Subject(s) - myelofibrosis , preleukemia , trisomy , medicine , polycythemia vera , myeloproliferative disorders , chromosome , leukemia , karyotype , pathology , acute leukemia , cytogenetics , trisomy 8 , bone marrow , gastroenterology , biology , genetics , gene
Cytogenetic studies were done on 18 patients with myelofibrosis or the closely related syndrome, undifferentiated myeloproliferative disorder (MPD). Clones of cells with chromosome abnormalities were demonstrated in the blood of eight individuals, including two with a history of radiation therapy and two with “acute myelofibrosis.” Trisomy 8 was present in the latter two patients, but otherwise, there was no consistent cytogenetic pattern or correlation with specific hematologic findings. Sixteen of these patients have been followed for more than 1 year or until death; none has progressed to leukemia. The results indicate that chromosome abnormalities are relatively common in this disorder, but as with polycythemia vera, and unlike some other “preleukemic” states, the aberrant clones in myelofibrosis do not appear to indicate that clinical leukemia is imminent.