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Ultrastructural, histochemical, and biochemical studies of two cases with amylase, ACTH, and β‐MSH producing tumor
Author(s) -
Gomi Kunihide,
Kameya Toru,
Tsumuraya Masaru,
Shimosato Yukio,
Zeze Fujio,
Abe Kaoru,
Yoneyama Takeshi
Publication year - 1976
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197610)38:4<1645::aid-cncr2820380434>3.0.co;2-j
Subject(s) - ultrastructure , amylase , cytoplasm , zymogen , immunofluorescence , pathology , endocrinology , microbiology and biotechnology , medicine , enzyme , chemistry , biology , biochemistry , antibody , immunology
Two cases of intrathoracic tumor, different in histology and accompanied by hyperamylasemia, were studied ultrastructurally, histochemically, and biochemically. The ultrastructure of the tumor cell cytoplasm showed many zymogen granules in case 1 and smaller cored granules in addition to zymogen granules in case 2. Both tumors contained npt only a large amount of amylase, which was electrophoretically of saliva type with three components, but also significant amounts of immunpreactive ACTH and β‐MSH. Starch film and immunofluorescence showed that the tumor cells stored amylase. It was concluded from these findings that the tumor cells ectopically producing amylase, which showed differentiation toward the cells with zymogen production, could differentiate toward the cells of ACTH‐MSH system at the same time.