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Chemoimmunotherapy for maintenance in acute myeloblastic leukemia
Author(s) -
Whiteside M. G.,
Cauchi M. N.,
Paton Christine,
Stone Janey
Publication year - 1976
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197610)38:4<1581::aid-cncr2820380423>3.0.co;2-y
Subject(s) - chemoimmunotherapy , medicine , acute myeloblastic leukemia , chemotherapy , maintenance therapy , complete remission , surgery , cyclophosphamide , leukemia , gastroenterology
Of 30 adult patients with acute myeloblastic leukemia, 14 achieved complete remission. Eight of these were given chemoimmunotherapy for maintenance. The immunotherapy consisted of intradermal pooled allogeneic leukemic cells (snap‐frozen irradiated) and BCG vaccine given by Heaf gun, given twice in 4 weeks. The chemotherapy was given for 1 week in 4 weeks. The median duration of remission in these eight patients was 115+ weeks and the median duration of survival was 147+ weeks. The other six patients who were given chemotherapy only for maintenance had a median duration of remission of 15 weeks and a median survival of 52 weeks. The two groups cannot be compared properly, however, as allocation of patients was not random, and the chemotherapy differed significantly.