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111 indium bone marrow scintigraphy as an aid in selecting marrow biopsy sites for the evaluation of marrow elements in patients with lymphoma
Author(s) -
Gilbert Edward H.,
Earle John D.,
Glatstein Eli,
Goris Michael L.,
Kaplan Henry S.,
Kriss Joseph P.
Publication year - 1976
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197610)38:4<1560::aid-cncr2820380419>3.0.co;2-m
Subject(s) - medicine , bone marrow , biopsy , leukopenia , lymphoma , sampling (signal processing) , bone marrow examination , scintigraphy , anemia , leukemia , radiology , pathology , chemotherapy , surgery , filter (signal processing) , computer science , computer vision
One hundred and two previously treated lymphoma patients were studied with 111 Indium bone marrow scans and bone marrow biopsies. The biopsies were considered to represent sampling errors when the cellularity of the biopsy did not reflect the general state of the marrow organ cellularity as demonstrated by the scan. In each instance the accuracy of the scan was confirmed by either another biopsy or the subsequent clinical course of the patient. Sampling errors were infrequent (1/51) in patients with normal peripheral blood counts and whose marrow had never been involved with tumor. Errors were especially likely (17/51) in patients who had had marrow involvement or those who had anemia, leukopenia, or thrombocytopenia. The 111 Indium bone marrow scan allows the clinician to avoid selecting a biopsy site with a high risk for sampling error.