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Fluorouracil, methyl‐ccnu and vincristine in cancer of the colon
Author(s) -
Falkson Geoffrey,
Falkson HendréC.
Publication year - 1976
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197610)38:4<1468::aid-cncr2820380403>3.0.co;2-k
Subject(s) - fluorouracil , medicine , vincristine , colorectal cancer , lomustine , regimen , oncology , cancer , chemotherapy , gastroenterology , surgery , cyclophosphamide
In a randomized study 91 patients with metastatic cancer of the colon were treated with either fluorouracil alone or a combination of fluorouracil, methyl‐CCNU, and vincristine. Of those treated with the three‐drug combination, 37% responded, and of those treated with fluorouracil alone, 22% responded. Median response duration for patients treated with the combination method was 5.0 months and for those with fluorouracil alone, 3.8 months. Toxic effects are also compared. From this study it is concluded that a three‐drug regimen provides a definite advantage.