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Granulocyte transfusions in children using filter‐collected cells
Author(s) -
Higby Donald J.,
Freeman Arnold,
Henderson Edward S.,
Sinks Lucius,
Cohen Elias
Publication year - 1976
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197609)38:3<1407::aid-cncr2820380347>3.0.co;2-s
Subject(s) - medicine , leukapheresis , chills , granulocyte , pneumonia , neutropenia , surgery , antibiotics , postoperative fever , intensive care medicine , chemotherapy , genetics , percutaneous , stem cell , cd34 , microbiology and biotechnology , biology
Twenty‐three children with various stages and morphologic types of leukemia were treated with multiple granulocyte transfusions obtained by filtration leukapheresis when neutropenia‐associated infection appeared unresponsive to antibiotics. All children meeting the above qualifications were given granulocyte transfusions during this time period. Twenty‐one of 23 became afebrile during or shortly after the transfusions; one died with disseminated Herpes simplex; and one became well enough to be discharged, although he was never free of fever. Frequent mild to moderate fever and chills were noted. One child developed a severe pulmonary reaction followed by resolution of pneumonia. Filtration leukapheresis is a useful adjunct in controlling severe infections in neutropenic children.