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Skin ulcers due to adriamycin
Author(s) -
Rudolph Ross,
Stein Richard S.,
Pattillo Roland A.
Publication year - 1976
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197609)38:3<1087::aid-cncr2820380308>3.0.co;2-x
Subject(s) - medicine , skin grafting , granulation tissue , surgery , dorsum , complication , necrotic tissue , tissue necrosis , dermatology , wound healing , anatomy
Abstract Local skin necrosis at the site of intravenous or intra‐arterial adriamycin infusion is an infrequent, but serious complication. Ulcers secondary to adriamycin have insidious beginnings, but progress to a much deeper extent than would be expected from their initial appearance. Deep structures, such as tendon or bone, may become exposed. The ulcers are indolent and do not develop a granulation tissue response or epithelialization, as might be expected from their early appearance. Injections of adriamycin in the dorsum of the hand should be avoided when possible, since tendons have little skin cover and the area is difficult to cover with local tissue if there is skin loss. While prevention is important, early surgical treatment may prevent progressive deep involvement and seems warranted when the patient has a life expectancy of months or years. Wide excision of all inflamed tissue is the treatment of choice, with split‐thickness skin grafting or flap coverage.