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Primary liver cell carcinoma in the presence or absence of hepatitis b antigen
Author(s) -
Fisher Rosemarie Lucianin,
Scheuer Peter J.,
Sherlock Sheila
Publication year - 1976
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197608)38:2<901::aid-cncr2820380237>3.0.co;2-d
Subject(s) - hbsag , medicine , carcinoma , hepatocellular carcinoma , gastroenterology , ascites , population , liver cell , hepatitis , hepatitis b , hepatitis b virus , pathology , immunology , virus , environmental health
The clinical course and pathological patterns of a group of 13 patients with both primary liver cell carcinoma and Hepatitis B surface antigen (HB s Ag) are described and contrasted with those of 43 patients with primary liver cell carcinoma but without HB s Ag. HB s Ag‐positive carcinoma patients demonstrated a higher incidence of splenomegaly, transudative ascites, and the presence of alpha‐fetoprotein, although none of these reached statistical significance. Serum bilirubin was significantly higher in patients with HB s Ag. HB s Ag‐positive carcinoma patients most frequently originated from countries where the presence of HB s Ag is high in the general population. Survival time from the diagnosis of primary liver cell carcinoma was shorter in patients with HB s Ag.