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Distribution of adenosine triphosphatase in infiltrating ductal carcinoma and non‐neoplastic breast
Author(s) -
Buell Richard H.,
Tremblay Gilles,
Rowden Geoffrey
Publication year - 1976
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197608)38:2<875::aid-cncr2820380235>3.0.co;2-3
Subject(s) - myoepithelial cell , pathology , ductal carcinoma , ductal cells , carcinoma , atpase , apocrine , breast carcinoma , fibroadenoma , mammary gland , medicine , biology , breast cancer , immunohistochemistry , cancer , enzyme , biochemistry
The histochemical reaction for adenosine triphosphatase (ATPase) has previously been used to differentiate myoepithelial from epithelial cells in the breast and to investigate the possible contribution of myoepithelial cells to mammary carcinoma. Discrepancies in published reports prompted this study of ATPase in non‐neoplastic breast and infiltrating ductal carcinoma. ATPase was localized mainly on myoepithelial cells of normal breast and was identified with significant frequency on epithelial cells in hyperplastic ducts. Infiltrating ductal carcinomas usually displayed a variable reactivity. In one instance, malignant cells demonstrating mucin production were found to be ATPase‐positive. An infiltrating ductal carcinoma of the papillary type with apocrine features was also strongly ATPase‐reactive. It is concluded that ATPase is not an exclusive marker of myoepithelial cells and, therefore, data resulting from the use of this enzyme to study the role of the myoepithelium in mammary carcinoma must be interpreted with caution.