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The chromosomes and causation of human cancer and leukemia. XIX. Common markers in various tumors
Author(s) -
Kakati Surabhi,
Oshimura Mitsuo,
Sandberg Avery A.
Publication year - 1976
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197608)38:2<770::aid-cncr2820380220>3.0.co;2-0
Subject(s) - causation , medicine , cancer , leukemia , cancer research , pathology , oncology , epistemology , philosophy
Most human cancers are associated with abnormal (marker) chromosomes. In past and present studies banding analyses have uncovered a much larger number of markers in cancer cells than was seen with standard (Giemsa) staining. Furthermore, common markers of identical morphology and origin were found in tumors of related or unrelated tissues or organs, suggesting that in all probability such markers, although present in cancers of diverse nature, may indicate a common etiology, either related to the causation of the cancers, to the progression of the tumors, or to the predilection of certain chromosomes to undergo morphologic changes leading to marker formation. Even though some markers were common to different tumors, the bulk of the markers in the cancers studied could not be identified with certainty and their nature varied from tumor to tumor.