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Sequential and combination chemotherapy of advanced gastric cancer
Author(s) -
Moertel Charles G.,
Mittelman James A.,
Bakemeier Richard F.,
Engstrom Paul,
Hanley James
Publication year - 1976
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197608)38:2<678::aid-cncr2820380209>3.0.co;2-s
Subject(s) - cyclophosphamide , medicine , chemotherapy , fluorouracil , cancer , toxicity , induction chemotherapy , nitrogen mustard , oncology , gastroenterology
One hundred and forty‐six previously untreated patients with advanced gastric cancer were assigned at random to therapy with the following regimens: 1) Methyl CCNU alone; 2) Methyl CCNU with cyclophosphamide induction; 3) 5‐fluorouracil (5‐FU) + methyl CCNU; and 4) 5‐FU + methyl CCNU with cyclophosphamide induction. Cyclophosphamide induction produced an objective response rate of only 8%. In addition, it added to hematologic toxicity and detracted from the therapeutic activity of subsequent treatment. Methyl CCNU was relatively ineffective therapy with an overall objective response rate of 8%. The response rate to 5‐FU + methyl CCNU without cyclophosphamide induction was 40% and this was significantly superior to all other regimens. The survival time of all patients treated with 5‐FU + methyl CCNU was significantly superior to that of all patients treated with methyl CCNU alone.