Premium
Preoperative radiation therapy for carcinoma of the esophagus
Author(s) -
Marks Richard D.,
Scruggs Hugh J.,
Wallace Keene M.
Publication year - 1976
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197607)38:1<84::aid-cncr2820380115>3.0.co;2-s
Subject(s) - medicine , esophagus , carcinoma , radiation therapy , surgery , stomach
From 1960 through 1973, 415 patients with carcinoma of the esophagus were treated with radiation therapy. Three hundred and thirty‐two patients had planned preoperative irradiation to a dose of 4500 rads in 18 fractions, and 101 of these had subsequent resections with either colon or stomach replacement. The operative mortality in this group was 18% and the 2‐ and 5‐year survivals were 22.8 and 13.6%, respectively. The dose of 4500 rads in 18 fractions produced tumor sterilization in 3% and reduction to in situ carcinoma in 10% of these 101 patients. The survival was considerably improved in this small group of patients. Those patients not amenable to exploration had a 3% 5‐year and a 5.6% 2‐year survival. Thirty‐three patients were given high‐dose curative radiation therapy and the 2‐year survival was 12.1%. The overall survival was 9% at 2 years and 6% at 5 years. The results in this series are compared with the most recent reports in the literature.