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Perspectives on the use of microspectrophotometry in the diagnosis of pretumorous processes and malignant tumors
Author(s) -
Avtandilov G. G.
Publication year - 1976
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197607)38:1<254::aid-cncr2820380138>3.0.co;2-o
Subject(s) - feulgen stain , malignancy , pathology , dna , larynx , nuclear dna , malignant transformation , biology , medicine , anatomy , genetics , gene , mitochondrial dna
Comparative microspectrophotometric study of the nuclear Feulgen DNA content in pretumorous processes and cancers (larynx, endometrium, large intestine, and stomach) has made it possible to formulate an exponential law of DNA accumulation in cell populations in proliferating and malignant tissue. The dynamics of changes in the “index of DNA accumulation” can be used as an objective quantitative diagnostic test. A scale of malignant transformation was proposed, with which the degree of probability of malignancy in pretumorous processes could be estimated. The data obtained allowed the author to propose a hypothesis of DNA superproduction as the basic cause of progressive neoplastic growth.