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Simultaneous occurrence of melanotic neuroectodermal tumor and brain heterotopia in the oropharynx
Author(s) -
Lee S. C.,
Henry M. M.,
GonzalezCrussi F.
Publication year - 1976
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197607)38:1<249::aid-cncr2820380137>3.0.co;2-d
Subject(s) - medicine , heterotopia (medicine) , pathology
A case is described of heterotopic brain tissue with simultaneous occurrence of melanotic neuroectodermal tumor in the oropharynx of a 6‐week‐old infant. The melanotic neuroectodermal tumor was embedded within the heterotopic glial tissue. This coexistence leads us to speculate that a defect causing a pinching‐off of both neural crest cap and medullary epithelium of neural tube might have taken place at, or before, the 25–30 somite stage. The displaced embryonic structures subsequently differentiated into glial tissue, choroid plexus, and melanotic neuroectodermal tumor. This observation may be interpreted as further support in favor of a neural crest origin of juvenile melanotic neuroectodermal tumor.