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Melanoma. Tumor angiogenesis and human neoplasia
Author(s) -
Hubler W. R.,
Wolf J. E.
Publication year - 1976
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197607)38:1<187::aid-cncr2820380129>3.0.co;2-d
Subject(s) - cheek pouch , angiogenesis , medicine , melanoma , neovascularization , hamster , pathology , cancer research
Transparent hamster‐cheek‐pouch chambers were used to document angiogenesis induced by implants of human malignant melanoma. Capillary proliferation was observed with direct implantation of melanoma fragments and with tumor implants placed on microporous membrane Filters. The pattern of capillary neovascularization was recorded and correlated with clinical and histopatho‐logic parameters.