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Radiation reaction of rat skin. The role of the number of fractions and the overall treatment time
Author(s) -
Moulder John E.,
Fischer James J.
Publication year - 1976
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197606)37:6<2762::aid-cncr2820370629>3.0.co;2-o
Subject(s) - medicine , stimulation , skin reaction , irradiation , nuclear medicine , immunology , physics , nuclear physics
Acute skin reactions resulting from orthovoltage x‐irradiation were measured in the WAG/Rij rat. A wide range of combinations of fraction number and overall time were used in an attempt to determine their relative importance. There appeared to be little effect of prolongation of overall treatment time until periods of over 2 weeks were reached. In treatment periods of 3 weeks and over the stimulation of extensive time‐dependent recovery was seen. A model based on cell kill with provision for the stimulation of accelerated proliferation at about 17 days adequately describes the experimental results.