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Fast neutron radiotherapy for locally advanced pelvic cancer
Author(s) -
Caderao J. B.,
Hussey D. H.,
Fletcher G. H.,
Sampiere V. A.,
Johnson D. E.,
Wharton J. T.
Publication year - 1976
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197606)37:6<2620::aid-cncr2820370609>3.0.co;2-2
Subject(s) - medicine , neutron , nuclear medicine , radiation therapy , neutron radiation , beam (structure) , neutron temperature , radiology , optics , nuclear physics , physics
Between March 1973 and May 1975, 82 patients with locally advanced pelvic tumors were treated with 50 MeV d→Be neutrons. Seventy‐nine have been included for analysis. The clinical material included 51 patients with gynecologic cancers, 15 with colorectal adenocarcinomas, and 13 with prostatic adenocarcinomas. Three treatment approaches have been used: 1) neutrons only—160 rad νγ twice weekly, 2) neutron boost following 25 MV photon irradiation—160 rad νγ twice weekly, and 3) mixed beam—photons (200 rads) three times weekly and neutrons (65 rad νγ ) twice weekly. The preliminary results with the mixed beam are superior to those obtained with neutrons only or a neutron boost. However, the patients treated with the mixed beam have presented with slightly less advanced cancer and have been treated to slightly higher equivalent doses than those treated with neutrons only. The superior results with the mixed beam may be related to a better volume distribution and/or five‐times weekly fractionation.