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Localized submassive liver cell necrosis as a terminal event of liver carcinoma
Author(s) -
Okuda Kunio,
Musha Hirotaka,
Kanno Harushige,
Igarashi Masahiko,
Nakano Masayuki,
Shimokawa Yutaka,
Kubo Yasuhiko,
Arishima Tsuneaki,
Hashimoto Masaharu,
Nagata Eisuke,
Kojiro Masamichi,
Sakamoto Kazuyoshi,
Nakashima Toshiro
Publication year - 1976
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197604)37:4<1965::aid-cncr2820370448>3.0.co;2-p
Subject(s) - medicine , hepatocellular carcinoma , autopsy , pathology , parenchyma , necrosis , liver parenchyma , metastatic carcinoma , carcinoma , sudden death , thrombosis , liver cell
Six cases of hepatocellular carcinoma (HCC) and one case of metastatic liver carcinoma in which SGOT, SGPT, and SLDH were suddenly and markedly elevated immediately before death are described. All had a large blood loss and systemic hypotension in the preterminal period; autopsy disclosed irregularly shaped, patchy necrotic areas or infarcts, often clearly demarcated by hemorrhagic rims, in the noncancerous liver parenchyma. Tumor growths in the intrahepatic portal branches were extensive in all six cases with HCC; in the metastatic case, invasion and narrowing of the portal branches were extensive. The incidence of this terminal catastrophe was 3.3% (6 of 184 cases) for HCC and 1.15% (1 of 87) for metastatic carcinoma. The terminal liver necrosis was probably a result of sudden reduction in portal perfusion which had been inadequate because of tumor thrombosis, combined with hypotension of hepatic arteries.