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Malignant ovarian tumors in childhood. Prognosis in relation to initial therapy
Author(s) -
Wollner Norma,
Exelby Philip R.,
Woodruff James M.,
Cham William C.,
Murphy M. Lois,
Lewis John L.
Publication year - 1976
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197604)37:4<1953::aid-cncr2820370447>3.0.co;2-z
Subject(s) - medicine , radiation therapy , regimen , endodermal sinus tumor , chemotherapy , disease , surgery , modalities , treatment modality , therapeutic modalities , germ cell tumors , social science , sociology
Twenty‐two children with malignant ovarian tumors (12 malignant teratomas, six endodermal sinus tumors, and four embryonal carcinomas) were studied from 1960 through March 1975. Comparison is made between different modalities of therapy, such as surgery alone or surgery in combination with either radiation or chemotherapy. Because of the poor results obtained with the aforementioned treatment methods, a new approach, consisting of more aggressive initial surgery followed immediately by radiation therapy and an intensive chemotherapeutic regimen called the T 2 protocol, was begun in 1971 with encouraging results. To date six of ten patients are alive and free of disease with a median observation period of 22+ months. A new grouping defining the extent of disease is also provided. Of the ten patients on the T 2 protocol, only one was a Group I; eight were Group III and one was Group IV at the time treatment was initiated. An analysis of the mode of spread, as well as a discussion of the results obtained with previous modalities of therapy in relation to initial grouping and pathology, constitute the background for the proposed treatment.