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Impairment of rosette‐forming T lymphocytes in patients with primary intracranial tumors
Author(s) -
Brooks William H.,
Roszman Thomas L.,
Rogers Alice S.
Publication year - 1976
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197604)37:4<1869::aid-cncr2820370435>3.0.co;2-q
Subject(s) - medicine , rosette (schizont appearance) , antigen , rosette formation , t lymphocyte , immunology , in vitro , delayed hypersensitivity , lymphocyte , antibody , pathology , lymphocyte activation , t cell , immune system , biology , genetics
The percentage of T lymphocytes that form rosettes (RFC) with sheep erythrocytes (E rosettes), cutaneous delayed‐type hypersensitivity, and in vitro lymphocyte transformation was measured in 15 patients with primary intracranial tumors. The ability of T lymphocytes to form E rosettes was significantly impaired. These patients also exhibited impaired ability to become sensitized to dinitrochlorobenzene and humoral suppression of PHA‐induced lymphocyte blastogenesis. The hypothetical role of antibody(s) to possible shared antigenic determinants on brain and T cells is discussed.