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Chromosomal mosaicism associated with prolonged remission in chronic myelogenous leukemia
Author(s) -
Golde David W.,
Bersch Noelle L.,
Sparkes Robert S.
Publication year - 1976
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197604)37:4<1849::aid-cncr2820370432>3.0.co;2-0
Subject(s) - chronic myelogenous leukemia , clone (java method) , stem cell , medicine , leukemia , bone marrow , cancer research , philadelphia chromosome , in vitro , immunology , pathology , biology , chromosomal translocation , genetics , dna , gene
The nature of the relationship between normal stem cells and the leukemic cells of chronic myelogenous leukemia (CML) is of considerable theoretical and practical importance. We studied a patient with CML who has maintained a complete hematologic remission for eight years without therapy. Presently, the only documentable abnormality is mosaicism for the Philadelphia (Ph 1 ) chromosome. Studies of his bone marrow in vitro revealed normal colony formation in agar and normal cellular proliferation and differentiation in liquid culture. Observations in this patient indicate that a Ph 1 ‐positive clone may coexist with normal stem cells during prolonged remissions in CML and the Ph 1 ‐positive cells may not always have a growth advantage over normal cells. The culture studies further suggest that the diminished proliferative capacity of the leukemic cells was not due to in vivo host suppressive factors.