Premium
Intracytoplasmic hyaline globules in hepatocellular carcinomas
Author(s) -
Cohen Cynthia
Publication year - 1976
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197604)37:4<1754::aid-cncr2820370421>3.0.co;2-l
Subject(s) - hyaline , medicine , pathology , dysplasia , cirrhosis , necrosis , hepatocellular carcinoma , gastroenterology , cancer research
Intracytoplasmic hyaline globules (IHG) were found in 16 out of 105 hepatocellular carcinomas (15.2%). In all cases, there was a male preponderance, most of the patients were Black, and the mean age was in the fifth decade. IHG were mostly noted in the better‐differentiated tumors. Bile production was present in 12% of all tumors. Over 80% of tumors with globules showed necrosis as compared with 40% of the tumors without globules. Cirrhosis was present in almost half the cases, with liver cell dysplasia in 15%. These globules are possibly alpha‐fetoprotein. Some of them may be giant lysosomes. Their role in carcinogenesis and prognosis is uncertain.