Premium
Bone marrow scanning with 52 iron ( 52 Fe)—Regeneration and extension of marrow after ablative doses of radiotherapy
Author(s) -
Knospe W. H.,
Rayudu V. M. S.,
Cardello M.,
Friedman A. M.,
Fordham E. W.
Publication year - 1976
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197603)37:3<1432::aid-cncr2820370326>3.0.co;2-u
Subject(s) - medicine , bone marrow , regeneration (biology) , radiation therapy , ablative case , irradiation , surgery , nuclear medicine , pathology , biology , physics , nuclear physics , microbiology and biotechnology
Extensively irradiated patients were studied from 0 to 73 months after irradiation by 52 Fe bone marrow scanning. Marrow regeneration was observed in most patients after intervals of 12 months or longer. The degree of recovery was not dose‐related and the marrow ablative dose was not defined with doses of 4000–5000 rads. Degree of recovery depended more upon the antomic region and/or sequence of fields treated; the last field treated invariably showed poorer regeneration when recovery was uneven. Active erythropoiesis expanded into distal inactive erythropoietic sites from 3–12 months after irradiation and then decreased thereafter. Blood count cytopenias were almost always restricted to the first year after irradiation.