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Acute myelomonocytic leukemia associated with paraproteinemia
Author(s) -
Law Ivan P.,
Koch Frederick J.,
Can Grace B.,
Herberman Ronald B.,
Oldham Robert K.
Publication year - 1976
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197603)37:3<1359::aid-cncr2820370316>3.0.co;2-b
Subject(s) - paraproteinemia , bence jones protein , medicine , acute myelomonocytic leukemia , chronic myelomonocytic leukemia , pathology , leukemia , cytochemistry , immunofluorescence , antibody , bone marrow , immunoglobulin light chain , myelodysplastic syndromes , immunology , multiple myeloma , ultrastructure
A 49‐year‐old white woman with refractory anemia subsequently developed acute myelomonocytic leukemia with paraproteinemia 12 months later. The paraprotein was characterized as immunoglobulin G, type kappa, and the Bence Jones protein as free kappa chains. Further studies, including electron microscopy, cytochemistry, and immunofluorescence provided evidence for synthesis of the paraprotein, both in vivo and vitro, by the myelomonocytic leukemic cells.