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Combination chemotherapy with cyclophosphamide, vincristine, and prednisone in advanced non‐Hodgkin's lymphomas
Author(s) -
Portlock Carol S.,
Rosenberg Saul A.
Publication year - 1976
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197603)37:3<1275::aid-cncr2820370307>3.0.co;2-m
Subject(s) - medicine , vincristine , prednisone , cyclophosphamide , chemotherapy , bleomycin , splenectomy , surgery , working formulation , gastroenterology , oncology , non hodgkin's lymphoma , spleen
From July 1971 to July 1974, 58 patients with advanced non‐Hodgkin's lymphomas were treated with cyclophosphamide, vincristine, and prednisone (CVP) at Stanford Medical Center. Utilizing the histopathologic criteria of Rappaport et al., response to CVP was found to be significantly better in the nodular (96.6%) and the diffuse lymphocytic (100%) histologies as compared to the diffuse nonlymphocytic lymphomas (47.6%). A pathologically documented complete remission was obtained in 33.9% of patients and all but two remain disease free for periods of 2–28 months. Concurrent bleomycin was administered to 17 patients during CVP therapy and no improvement in response or median survival was noted. Prior radiation therapy delivered to 21 patients did not adversely affect their response to CVP or their survival. Splenectomy in 17 patients prior to CVP did not improve hematologic tolerance to chemotherapy except in those patients with prior radiation therapy, and there was no improvement in response to CVP or survival. CVP is effective in achieving complete remissions and extended disease‐free survivals in advanced non‐Hodgkin's lymphomas; both a nodular architecture and a diffuse lymphocytic histology are positive determinants for response to chemotherapy and improved median survival.