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Chronic neurologic disturbance in childhood leukemia
Author(s) -
McIntosh Sue,
Klatskin Ethelyn H.,
O'Brien Richard T.,
Aspnes Gregg T.,
Kammerer Betsy L.,
Snead Carter,
Kalavsky Steven M.,
Pearson Howard A.
Publication year - 1976
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197602)37:2<853::aid-cncr2820370234>3.0.co;2-q
Subject(s) - medicine , disturbance (geology) , leukemia , childhood leukemia , chronic leukemia , intensive care medicine , pediatrics , immunology , acute leukemia , lymphoblastic leukemia , paleontology , biology
Twenty‐three leukemic children were studied prospectively to detect chronic effects of therapy. All patients received CNS prophylaxis, including 2400 R cranial irradiation, and intermittent maintenance therapy with intravenous methotrexate, cyclophosphamide and cytosine arabinoside. Neurologic symptoms were observed in 12 patients, all of whom had intermittent limping and mild incoordination, between the 10th and 18th month of maintenance therapy. Five of the 12 sustained seizures and four of these had subsequent abnormalities in motor, perceptual, behavioral or language development. Three school‐aged children have learning disability and perceptual‐motor defects. Studies of CSF folate and MTX content are presented but are not helpful in delineating the etiology of these neurologic symptoms.