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Sinus histiocytosis with massive lymphadenopathy. Fifteen new casesd
Author(s) -
Lampert Fritz,
Lennert Karl
Publication year - 1976
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197602)37:2<783::aid-cncr2820370226>3.0.co;2-l
Subject(s) - medicine , lymph node , titer , antibody titer , antibody , surgery , pathology , immunology
Fifteen cases of chronic lymphadenitis with massive hemophagocytic sinus histiocytosis were analyzed. Fourteen patients were whites, 13 were Europeans, and 11 were males; 10 patients were under 10, 4 were over 20, and 2 over 60 years old. The oldest patient died; all others either healed without therapy or are in excellent condition. We studied the cytologic features of lymph node imprints. A 5‐year‐old girl was examined more thoroughly. High antibody titers to Klebsiella antigens were found repeatedly. The patient also had a constant lymphocytopenia. Phytohemagglutinin‐induced blast transformation and lymphotoxin production were within normal limits. No serum Epstein‐Barr virus‐antibodies could be detected.