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Fetal antigens in retinoblastoma
Author(s) -
Michelson Joseph B.,
Felberg Norman T.,
Shields Jerry A.
Publication year - 1976
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197602)37:2<719::aid-cncr2820370217>3.0.co;2-8
Subject(s) - retinoblastoma , medicine , carcinoembryonic antigen , enucleation , radiation therapy , alpha fetoprotein , antigen , oncology , pathology , cancer , surgery , immunology , biology , biochemistry , gene , hepatocellular carcinoma
Plasma carcinoembryonic antigen (CEA) and alpha fetoprotein (AFP) levels were studied in five patients with retinoblastoma. CEA and AFP were found elevated in four of five patients prior to therapy. Following enucleation and/or radiation therapy, the elevated values were significantly lowered. This preliminary study suggests that CEA and AFP levels may be of value in the diagnosis of retinoblastoma, and that serial CEA levels may be useful in evaluation of retinoblastoma patients after treatment.