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T and B cells and cell‐mediated immunity in mycosis fungoides
Author(s) -
Nordqvist Barbro C.,
Kinney John P.
Publication year - 1976
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197602)37:2<714::aid-cncr2820370216>3.0.co;2-q
Subject(s) - mycosis fungoides , medicine , immunity , dermatology , immunology , lymphoma , immune system
T and B cells in peripheral blood were evaluated in 13 patients with mycosis fungoides (MF) and in two patients with Sálary's syndrome. T cells were identified by their capacity to bind sheep red blood cells to their surfaces and the B cells were identified by the presence of surface immunoglobulins in immunofluorescence assay. Seven patients with MF and two with Sázary's syndrome were shown to have T‐cell values below normal and elevated levels of null cells, i.e., cells with markers for neither T nor B cells. Low T‐cell values and elevated Null‐cell values were found predominantly in patients with advanced mycosis fungoides (stages III–IV). Furthermore, these patients had impaired cell‐mediated immunity, as shown by in vivo skin testing with recall antigens and attempts at sensitization to dinitrochlorobenzene.