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The cardiotoxicity of adriamycin and daunomycin in children
Author(s) -
Gilladoga Angela C.,
Manuel Corazon,
Tan Charlotte T. C.,
Wollner Norma,
Sternberg Stephen S.,
Murphy M. Lois
Publication year - 1976
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197602)37:2+<1070::aid-cncr2820370814>3.0.co;2-6
Subject(s) - medicine , cardiotoxicity , heart failure , cardiomyopathy , incidence (geometry) , cardiology , cumulative dose , chemotherapy , physics , optics
Eight (16%) of 50 children receiving adriamycin and 2 (3%) of 60 receiving daunomycin had severe cardiomyopathy with congestive heart failure. All 110 patients received cumulative doses of over 500 mg/m 2 . The incidence was significantly higher in those who also had incidental cardiac radiation. The electrocardiogram, with few exceptions, provided the first indication of cardiac abnormality. There were no deaths from heart failure. Two had thromboembolic episodes. Recommendations are discussed.