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Frequent low doses of intravenous mechlorethamine for late‐stage mycosis fungoides lymphoma
Author(s) -
van Scott Eugene J.,
Grekin David A.,
Kalmanson Jacob D.,
Vonderheid Eric C.,
Barry William E.
Publication year - 1975
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197511)36:5<1613::aid-cncr2820360513>3.0.co;2-0
Subject(s) - mycosis fungoides , medicine , nitrogen mustard , lymphoma , dermatology , stage (stratigraphy) , cutis , cutaneous t cell lymphoma , chemotherapy , surgery , cyclophosphamide , paleontology , biology
Ninety‐two courses of daily low‐dose intravenous nitrogen mustard were administered to 46 patients with advanced cutaneous lymphomas (mycosis fungoides, Sezary syndrome and lymphoma cutis). Seventy‐eight % of patients showed objective clinical remission, and 35% reached a clinically disease‐free state following 1 or more courses. The response rate was greater in patients with the plaque‐tumor type of mycosis fungoides than in those with erythrodermic variants. Therapy was free of significant side effects.