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Ectopic placental proteins in nontrophoblastic tumors. Serial measurements following chemotherapy
Author(s) -
Muggia Franco M.,
Rosen Saul W.,
Weintraub Bruce D.,
Hansen Heine H.
Publication year - 1975
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197510)36:4<1327::aid-cncr2820360421>3.0.co;2-8
Subject(s) - medicine , concordance , human chorionic gonadotropin , human placental lactogen , gonadotropin , chemotherapy , carcinoma , placental lactogen , endocrinology , pathology , hormone , biology , pregnancy , placenta , fetus , genetics
Four men with metastatic carcinoma (two bronchus, one stomach, one primary unknown) and ectopic placental protein production (one chorionic gonadotropin (hCG and its alpha subunit; one placental lactogen (hPL); one hCG alone; one hCG and hPL) were studied with serial retrospective measurements of the ectopic protein concentrations in serum, correlated with objective assessment of clinical status. The biochemical marker and clinical response were documented during treatment with a variety of agents and during periods without therapy. Of nine assessable periods, seven showed concordance of biochemical marker and clinical responses.