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Hl‐a in cancer family “n”
Author(s) -
Lynch Henry T.,
Thomas Robert J.,
Terasaki Paul I.,
Ting Alan,
Guirgis Hoda A.,
Kaplan Arnold R.,
Magee Hugh,
Lynch Jane,
Kraft Carol,
Chaperon Edward
Publication year - 1975
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197510)36:4<1315::aid-cncr2820360419>3.0.co;2-t
Subject(s) - haplotype , cancer , medicine , odds ratio , family member , typing , genetics , biology , genotype , family medicine , gene
Actual HL‐A typing has been performed on 115 members of cancer family N, a large kindred (over 1000 members ascertained) showing the findings consistent with the cancer family syndrome. In the cancer‐prone line (branches C and D) of the family, 20 of 21 members with cancer had one HL‐A haplotype, HL‐A2‐HL‐A12 (relative odds ‐ 6.30), including some deceased family members who had haplotypes assigned. Eleven of 12 family members with cancer in branches C and D, actually typed, had HL‐A2‐HL‐A12 (relative odds = 6.06). The single exception showing cancer and another haplotype in branch D is a child of a family member with haplotype HL‐A2‐HL‐A12.