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Regression of pulmonary metastatic disease associated with intralesional bcg therapy of intracutaneous melanoma metastases
Author(s) -
Mastrangelo Michael J.,
Bellet Robert E.,
Berkelhammer Jane,
Clark Wallace H.
Publication year - 1975
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197510)36:4<1305::aid-cncr2820360417>3.0.co;2-#
Subject(s) - medicine , metastatic melanoma , melanoma , immunotherapy , metastasis , lung , disease , pathology , cancer , dermatology , cancer research
A 77‐year‐old white man with 64 intracutaneous melanoma metastases and a pulmonary metastatic deposit was treated with immunotherapy. Over an 8‐month period, 17 intracutaneous lesions were inoculated with BCG. All 17 injected lesions and all 47 uninjected intracutaneous lesions resolved; no new nodules appeared and the pulmonary metastasis regressed (> 50%). This is the first documeted case of a pulmonary metastatic focus responding to intralesional BCG therapy of intracutaneous metastases.