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A comparison of nitrogen mustard, vincristine, procarbazine, and prednisone (mopp) vs. nitrogen mustard in advanced hodgkin's disease
Author(s) -
Huguley Charles M.,
Durant John R.,
Moores Russell R.,
Chan YickKwong,
Dorfman Ronald F.,
Johnson Lorraine
Publication year - 1975
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197510)36:4<1227::aid-cncr2820360408>3.0.co;2-t
Subject(s) - procarbazine , nitrogen mustard , vincristine , prednisone , medicine , chemotherapy , surgery , oncology , gastroenterology , cyclophosphamide
A randomized study of patients with advanced Hodgkin's disease was designed to determine whether the improved therapeutic effectiveness of combination chemotherapy was due to the use of a combination of drugs or might be achieved with a single agent if given as intensively and for as long a period. A combination of nitrogen mustard, vincristine, procarbazine, and prednisone (MOPP) was compared with nitrogen mustard (HN 2 ) alone. Treatment with both regimens was given to tolerance on cyclic basis and was continued for six cycles of treatment. Sixty‐one evaluable patients were treated with MOPP and 47 with HN 2 . The complete remission rate of 47.5% with MOPP was significantly better than the 12.8% with HN 2 (p < .05). Complete remission lasted a median of 15 months after MOPP and 12 months after HN 2 . The survival of patients initially treated with MOPP was significantly better than that of those initially treated with HN 2 .