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Clear cell sarcoma with melanin pigment
Author(s) -
Bearman Robert M.,
Noe Joel,
Kempson Richard L.
Publication year - 1975
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197509)36:3<977::aid-cncr2820360321>3.0.co;2-d
Subject(s) - melanosome , melanin , clear cell sarcoma , melanoma , pathology , sarcoma , medicine , neoplasm , soft tissue , soft tissue sarcoma , cell , biology , cancer research , genetics
A patient with a clear cell sarcoma of tendons and aponeuroses arising in the left sacral area is reported. The tumor grossly contained two black foci that had pigment with the staining charcteristics of melanin on light microscopy. Electron microscopy of these areas showed the pigment to be within melanosomes. This is the second report of a neoplasm diagnosed as clear cell sarcoma in which melanin was demonstrated; the possibility that the tumor represents a soft tissue variant of malignant melanoma is discussed. It is suggested that clear cell sarcoma is a heterogeneous entity, and that a number of different soft tissue neoplasms may present with a clear cell pattern, making diagnosis and classification difficult.