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Evaluation of methotrexate in the treatment of bronchogenic carcinoma
Author(s) -
Vincent R. G.,
Pickren J. W.,
Fergen T. B.,
Takita H.
Publication year - 1975
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197509)36:3<873::aid-cncr2820360308>3.0.co;2-9
Subject(s) - bronchogenic carcinoma , medicine , methotrexate , carcinoma , placebo , chemotherapy , surgery , pharmacotherapy , oncology , gastroenterology , pathology , alternative medicine
One hundred ninety‐five patients with disseminated bronchogenic carcinoma were treated with 10 different dosage schedules of methotrexate. Patient response to methotrexate therapy varied with the type of treatment, but overall, 18% of the patients treated responded to a measurable degree. Survival was not increased in any of the treatment categories when compared to a placebo group; however, the survival of patients that responded to therapy was greater than the survival of patients that did not respond to therapy. Methotrexate will find its greatest potential use in combination with other drugs proven to be effective in treating bronchogenic carcinoma.