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Glycogen‐rich adenocarcinoma of minor salivary glands. A light and electron microscopic study
Author(s) -
Mohamed A. H.,
Cherrick H. M.
Publication year - 1975
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197509)36:3<1057::aid-cncr2820360332>3.0.co;2-p
Subject(s) - glycogen , basement membrane , pathology , ultrastructure , electron microscope , anatomy , basal lamina , chemistry , biology , medicine , endocrinology , physics , optics
A malignant glycogen‐rich adenocarcinoma of palatal salivary glands is reported. Histopathology revealed nonencapsulated nests and cords of polyhedral cells showing voluminous clear cytoplasms and cellular pleomorphisms, separated by fine vascular septae. Small and large ducts were infrequently seen showing apparent transition of large ducts into clear cells. The tumor cells were PAS‐ and Best‐carmine positive, diastase soluble, and mucicarmine and Alcian‐blue negative. Ultrastructurally, the tumor cells were arranged in solid nests and cords of electron‐lucent cells surrounding single or multiple lumina, and surrounded by basement lamina. Occasional fusiform electron‐dense cell processes were present beneath the basement lamina. The electron‐lucent cells were joined by junctional complexes, contained intracytoplasmic canals, and were filled with massive accumulations of β glycogen particles. The electron‐dense processes contained interlacing whorls of fine filaments and exhibited peripheral focal densities. The findings suggest that this glycogen‐rich malignant tumor is of epithelial origin most probably of ductal cells.