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PH 1 ‐positive megakaryoblastic leukemia
Author(s) -
Hossfeld D. K.,
Tormey D.,
Ellison R. R.
Publication year - 1975
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197508)36:2<576::aid-cncr2820360237>3.0.co;2-g
Subject(s) - hepatosplenomegaly , medicine , acute megakaryoblastic leukemia , bone marrow , essential thrombocythemia , leukemia , pathology , cancer research , platelet , immunology , disease
Abstract A case of megakaryoblastic leukemia is presented. Megakaryoblastosis and erythrocytic hyperplasia of the bone marrow, thrombocythemia, and hepatosplenomegaly were the essential features; 100% of the marrow‐derived metaphases were found to be Ph 1 ‐positive. Cytologic and chromosomal findings are compatible with the assumption that all three marrow systems were involved in the leukemic process.