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Comparison of alpha 1 fetoprotein radioimmunoassay method and liver scanning for detecting primary hepatic cell carcinoma
Author(s) -
Tonami Norihisa,
Aburano Tamio,
Hisada Kinichi
Publication year - 1975
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197508)36:2<466::aid-cncr2820360224>3.0.co;2-u
Subject(s) - medicine , radioimmunoassay , scintigraphy , carcinoma , pathology , hepatocellular carcinoma , liver cell , radiology , titer , alpha fetoprotein , nuclear medicine , antibody , immunology
Alpha 1 (α 1 ) fetoprotein (AFP) radioimmunoassay method was routinely used in addition to liver scintigraphy to detect a primary hepatic cell carcinoma, and the diagnostic accuracy of both methods was compared. Twenty‐one of 27 cases (78%) with primary hepatic cell carcinoma showed a positive AFP titer of over 200 ng/ml. In 3 of these AFP‐positive cases, no focal defects could be found in liver scintigraphy, although subsequently performed celiac angiography revealed hypervascular shadows. On the contrary, 22 of 27 cases (81%) represented well‐defined focal defects on scintigraphy. In 4 of these cases with a positive scan, the result of AFP was found to be negative. The overall diagnostic accuracy for detecting primary hepatic cell carcinoma with a combination of both methods was 93%.